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50th ERA-EDTA Congress

 

May 18-21 2013 Istanbul
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Discussion forum - 50th ERA-EDTA Congress
    Topic - Acid-base / Electrolytes / Nephrolithiasis

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Poster: 289
Visits: 27
Title: SODIUM THIOSULFATE AMELIORATES OXIDATIVE STRESS AND PRESERVE RENAL FUNCTION IN ETHYLENE GLYCOL- TREATED RATS
Authors: Rakesh Bijarnia , Rakesh K Bijarnia,1 Andreas Pasch.1
Centre: Nephrology & Hypertension

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SODIUM THIOSULFATE AMELIORATES OXIDATIVE STRESS AND PRESERVE RENAL FUNCTION IN ETHYLENE GLYCOL- TREATED RATS

Rakesh Bijarnia
Thread initiator
Subspeciality
Reg: 4/25/2013 5:25:00 PM
Comment# 1
The pathogenesis of renal calculi requires formation of crystals and their retention in the renal tissue. The most predominant composition of renal calculi is calcium salts combined with either phosphate or oxalate. A series of reports have proposed that oxalate at higher concentrations causes oxidative stress in renal tissue. Thus, quenching oxidant burden appears to be a tangible way to combat the manifestations associated with renal calculi formation. To date, no anticalcifying compounds for the prevention of renal calculi have been invented into routine clinical practice. Sodium thiosulfate (STS) reduces kidney stone formation in humans and minimizes calcium phosphate kidney stone formation in hypercalciuric rats. The properties of STS might be related to its antioxidative effects. In the present study, the efficacy of STS to amend oxidative stress in ethylene glycol induced animal model and renal epithelial LLC-PK1 cells was studied.

Comment added on 4/25/2013 5:25:00 PM 
     
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